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Philippine Textbook Of Medical Parasitology By Belizario Pdf Download 118




released from the host cell (merozoic formation) to reinfect other cells. The resultant cysts are then taken up by the peripheral white blood cells and within the macrophage they are digested and transformed into an asexual phase of the lifecycle, in which large numbers of merozoites are released from the macrophage. The merozoites then enter red blood cells (pRBC) and develop into the sexual phase of the lifecycle, in which large numbers of sporozoites are released from the infected pRBC and the sexual phase is completed within a hepatocyte. At this point, the parasite is able to enter into a latent phase of the lifecycle, in which it is able to survive indefinitely without being able to cause any new infections. The parasite then becomes "cured" by being transmitted to a new host, in which it can cause an outbreak of disease, as occurs in all forms of malaria. The dormant liver stage may play a role in the development of liver cancer. Red blood cells. In the bloodstream, the parasite resides in the cytoplasm of a hepatocyte. The infected RBC has a characteristic protozoan appearance and a round-to-oval shape. There is no parasite stage of the lifecycle with a simple body shape, because the merozoite has a 2- to 3-μm length and a diameter of 1-3 μm. In the blood stream, a merozoite is approximately 0.1-0.2 μm in length. Infected red blood cells are carried through the blood stream until they come to a capillary where they fuse with the vascular endothelium and are phagocytosed by a white blood cell. The free merozoites enter the macrophage and mature into schizonts. The schizonts give rise to several daughter merozoites, which undergo schizogony and merozoic formation. The mature trophozoites are released from the macrophage and begin to invade red blood cells. Asexual growth The number of merozoites released by each schizont is estimated to be in the range of 1,000-5,000. During asexual growth, merozoites divide in the cell cytoplasm in a way that results in an average of 6 merozoites per daughter cell. The merozoites become immobile and gradually grow to a length




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Philippine Textbook Of Medical Parasitology By Belizario Pdf Download 118

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